‘Yes, that is certainly about right. I hunt for a Actual physical understanding of biological devices inside a bottom-up way. I feel you could distinguish 3 traces of investigate in my group at the moment. The primary fears chromosome structure: How would you have a metre-long DNA polymer folded and organised in such a microscopic cell? We now have made visualisation methods that enable us to review how, such as, SMC proteins loop DNA (video on Youtube) as a way to Create up chromosomes.
This issue is for tests if you are a human visitor and to forestall automatic spam submissions.
‘It was simply just a subject of selecting up a e-book on cell biology and beginning to go through. I had originate from a entire world of ultra-higher vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Non-equilibrium folding of person DNA molecules recaptured as much as 1000 occasions inside a solid state nanopore
2010, created a whole new way (‘wedging transfer’) to govern nanostructures; to start with report of DNA translocation via graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into sound-condition nanopores
Our analysis ranges from your biophysics of DNA to synthetic cells and past. Make sure you have a look below in the spectrum of our present projects.
A lot of linked developments adopted, where by our group established various transistor variants like single-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled numerous transistors into tiny proof-of-principle electronic circuits.
Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
What if, in lieu of making use of conventional top rated-down silicon electronics, transistors could possibly be built from The underside up using solitary organic molecules as being the switching components? This concept, which became The premise of these days’s industry of molecular electronics, very first emerged during the 1970s.
There was a person problem however — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up essentially not these terrific conductors, which was alternatively disappointing. We thus broadened our view to try to find more promising molecules.
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
1999, initially measurement from the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes
2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational variations in Mre11/DNA fix complexes; and to start with power measurements over a DNA cees dekker molecule inside a nanopore
Eventually, I'll briefly sketch many of our ideas to discover the creating of synthetic cells, exclusively our initially techniques to determine artificial mobile division.